Cutting-edge brain imaging technologies are being used to examine the neurobiological features associated with having a high risk for dementia

 

 
 
 
 
 

 

 

 

While the burden of dementia occurs late in life, neuropathology accumulates for decades prior to the onset of dementia. Interventions to modify the course of the disease have the greatest potential to avert neuronal death and later disease burden if introduced during this crucial window, well before the onset of clear cognitive decline. Thus, it is imperative to identify those neuropathological features at the very early stage of dementia.

The Prospective Imaging Study of Ageing (PISA) is a unique joint research program of QIMR Berghofer Medical Research Institute, CSIRO, The University of Queensland, Queensland Health and The University of Western Australia. This is a unique prospective, longitudinal study, which seeks to (1) Identify healthy middle-aged adults at high risk of dementia; (2) Discover biological and imaging markers of early neuropathology; (3) Identify modifiable risk factors, and (4) Establish the very early phenotypic and neuronal signs of disease conversion.

Combining longitudinal brain imaging, physiological and biological monitoring, PISA study will collect a large prospective dataset from a risk-enriched healthy cohort, and therein cutting-edge brain imaging technologies are being used to examine the neurobiological features associated with high risk for dementia.

We have developed and tested a comprehensive suite of imaging sequence on MRI and PET, including high resolution MP2RAGE, FLAIR, QSM, multi-band diffusion imaging, abdominal DIXON, fMRI, and amyloid-PET (Florbetaben).

Team and Contact

Dr Ying Xia: ying.xia@csiro.au

Dr Jurgen Fripp: Jurgen.fripp@csiro.au