Case study

14Mar 2018
Man Jogging

The Challenge: Patients aren’t completing rehab following total knee replacements Total knee replacement (TKR) is a procedure that has been rising steadily in recent years. In fact there was a 77 per cent increase in TKR surgeries from 2003 to 2014 in Australia, and this trend is likely to continue due to factors such as […]

09Mar 2018

Computational tools to improve genome engineering applications   The GT-Scan suite contains computational tools for efficiently solving the optimisation problem of identifying the most suitable target for genome engineering approaches, which requires to maximise on-target activity (guide efficiency) while also to minimise potential off-target effects (guide specificity). The GT-Scan suite is a machine learning framework […]

09Mar 2018

machine learning for population-scale whole genome data Genomic information is increasingly being used for medical research, giving rise to the need for efficient analysis methodologies able to cope with thousands of individuals and millions of genomic variants. We developed VariantSpark, a machine learning analysis framework for genomic data, utilizing the BigData Spark engine to enable […]

08Feb 2018

  The Challenge: Diabetic retinopathy screening can only be done by specialists Diabetic retinopathy is a complication affecting one in three people with diabetes. Without early detection and timely treatment, it can lead to partial loss of vision or blindness. Only specialists (ophthalmologists) can screen and diagnose people for this condition, so GPs refer at-risk […]

23Nov 2017
a range of line and bar graphs against a blurred purple background

The Challenge Search technologies are critical to enable clinical staff to rapidly and effectively access patient information contained in free-text medical records. Medical search is challenging as it suffers from the semantic gap problem: the mismatch between the raw data and the way a human being interprets it. Valuable domain knowledge explicitly represented in structured […]

23Nov 2017
droplets of moisture along the strands of a spiderweb

The Challenge Death certificates provide an invaluable source for mortality statistics, which can be used for surveillance and early warnings of increases in disease activity and to support the development and monitoring of prevention or response strategies. However, this value can be realised only if timely, accurate and quantitative data is extracted from death certificates, […]

23Nov 2017
Ones and zeros repeat in a circle.

Pathology notification for a Cancer Registry is regarded as the most valid information for the confirmation of a diagnosis of cancer. The development of a clinical decision support system to unlock information from medical free-text can significantly reduce costs arising from manual processes and enable improved decision support, enhancing efficiency and timeliness of cancer information […]

23Nov 2017
A flowchart shows the progression from data acquisition to cartilage biochemical properties

Osteoarthritis (OA) is a joint disease that is characterized by breakdown of joint cartilage and underlying bone. Traumatic injuries, such as a tear of the anterior cruciate ligament (ACL) increases the risk of developing OA and provide a targeted way to investigate early pathophysiological changes in cartilage and intervene in a disease process. Our current […]